8f6g
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BPTF bromodomain in complex with BZ2== | |
| - | + | <StructureSection load='8f6g' size='340' side='right'caption='[[8f6g]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8f6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F6G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XHK:6-[4-(2-aminoethyl)anilino]-5-chloro-3-methylpyrimidin-4(3H)-one'>XHK</scene></td></tr> |
| - | [[Category: Fischer | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f6g OCA], [https://pdbe.org/8f6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f6g RCSB], [https://www.ebi.ac.uk/pdbsum/8f6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f6g ProSAT]</span></td></tr> |
| - | [[Category: Nithianantham | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fischer M]] | ||
| + | [[Category: Nithianantham S]] | ||
Current revision
Crystal structure of BPTF bromodomain in complex with BZ2
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