8qpk

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'''Unreleased structure'''
 
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The entry 8qpk is ON HOLD until Paper Publication
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==Cryo-EM Structure of Pre-B+5'ss Complex (core part)==
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<StructureSection load='8qpk' size='340' side='right'caption='[[8qpk]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qpk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QPK FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qpk OCA], [https://pdbe.org/8qpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qpk RCSB], [https://www.ebi.ac.uk/pdbsum/8qpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qpk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PRP6_HUMAN PRP6_HUMAN] Retinitis pigmentosa. The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals.
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== Function ==
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[https://www.uniprot.org/uniprot/PRP6_HUMAN PRP6_HUMAN] Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.<ref>PMID:12039962</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dybkov O]]
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[[Category: Kastner B]]
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[[Category: Kumar V]]
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[[Category: Ludwig S]]
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[[Category: Luehrmann R]]
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[[Category: Stark H]]
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[[Category: Urlaub H]]
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[[Category: Will CL]]
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[[Category: Zhang Z]]
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[[Category: Zhong J]]

Revision as of 08:04, 22 May 2024

Cryo-EM Structure of Pre-B+5'ss Complex (core part)

PDB ID 8qpk

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