8ym7

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Current revision (08:08, 22 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ym7 is ON HOLD until Paper Publication
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==Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45==
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<StructureSection load='8ym7' size='340' side='right'caption='[[8ym7]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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Authors: Zhiyan, D., Danyan, C., Hong, J., Tongchao, L., Bing, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ym7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YM7 FirstGlance]. <br>
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Description: Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LZJ:4-[5-(4-azanylpiperidin-1-yl)-8-(4-methylphenyl)pyrido[3,4-b]pyrazin-7-yl]-2-fluoranyl-benzenecarbonitrile'>A1LZJ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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[[Category: Zhiyan, D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ym7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ym7 OCA], [https://pdbe.org/8ym7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ym7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ym7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ym7 ProSAT]</span></td></tr>
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[[Category: Bing, X]]
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</table>
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[[Category: Hong, J]]
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== Function ==
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[[Category: Tongchao, L]]
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[https://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>
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[[Category: Danyan, C]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bing X]]
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[[Category: Danyan C]]
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[[Category: Hong J]]
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[[Category: Tongchao L]]
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[[Category: Zhiyan D]]

Current revision

Crystal structure of Lysine Specific Demethylase 1 (LSD1) with JH-45

PDB ID 8ym7

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OCA

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