1s79

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1s79.gif|left|200px]]
[[Image:1s79.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1s79 |SIZE=350|CAPTION= <scene name='initialview01'>1s79</scene>
+
The line below this paragraph, containing "STRUCTURE_1s79", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SSB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1s79| PDB=1s79 | SCENE= }}
-
|RELATEDENTRY=[[1owx|1OWX]], [[1s7a|1S7A]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s79 OCA], [http://www.ebi.ac.uk/pdbsum/1s79 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s79 RCSB]</span>
+
-
}}
+
'''Solution structure of the central RRM of human La protein'''
'''Solution structure of the central RRM of human La protein'''
Line 32: Line 29:
[[Category: Kelly, G.]]
[[Category: Kelly, G.]]
[[Category: Sanfelice, D.]]
[[Category: Sanfelice, D.]]
-
[[Category: alpha/beta]]
+
[[Category: Alpha/beta]]
-
[[Category: rrm]]
+
[[Category: Rrm]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:23:05 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:38:20 2008''
+

Revision as of 05:23, 3 May 2008

Image:1s79.gif

Template:STRUCTURE 1s79

Solution structure of the central RRM of human La protein


Overview

The La protein is a conserved component of eukaryotic ribonucleoprotein complexes that binds the 3' poly(U)-rich elements of nascent RNA polymerase III (pol III) transcripts to assist folding and maturation. This specific recognition is mediated by the N-terminal domain (NTD) of La, which comprises a La motif and an RNA recognition motif (RRM). We have determined the solution structures of both domains and show that the La motif adopts an alpha/beta fold that comprises a winged-helix motif elaborated by the insertion of three helices. Chemical shift mapping experiments show that these insertions are involved in RNA interactions. They further delineate a distinct surface patch on each domain-containing both basic and aromatic residues-that interacts with RNA and accounts for the cooperative binding of short oligonucleotides exhibited by the La NTD.

About this Structure

1S79 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein., Alfano C, Sanfelice D, Babon J, Kelly G, Jacks A, Curry S, Conte MR, Nat Struct Mol Biol. 2004 Apr;11(4):323-9. Epub 2004 Mar 7. PMID:15004549 Page seeded by OCA on Sat May 3 08:23:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s79"
Personal tools