1v41

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Revision as of 17:34, 12 November 2007

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spinqualitylabelsall models 1v41, resolution 2.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of human PNP complexed with 8-Azaguanine

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Purine nucleoside phosphorylase (PNP) is a key enzyme in the, purine-salvage pathway, which allows cells to utilize preformed bases and, nucleosides in order to synthesize nucleotides. PNP is specific for purine, nucleosides in the beta-configuration and exhibits a strong preference for, purines containing a 6-keto group and ribosyl-containing nucleosides, relative to the corresponding analogues. PNP was crystallized in complex, with ligands and data collection was performed using synchrotron, radiation. This work reports the structure of human PNP in complex with, guanosine (at 2.80 A resolution), 3'-deoxyguanosine (at 2.86 A resolution), and 8-azaguanine (at 2.85 A resolution). These structures were compared, with the PNP-guanine, PNP-inosine and PNP-immucillin-H complexes solved, previously.

Disease

Known diseases associated with this structure: Neutral lipid storage disease with myopathy OMIM:[609059], Nucleoside phosphorylase deficiency, immunodeficiency due to OMIM:[164050]

About this Structure

1V41 is a Single protein structure of sequence from Homo sapiens with SO4 and AZG as ligands. Active as Purine-nucleoside phosphorylase, with EC number 2.4.2.1 Full crystallographic information is available from OCA.

Reference

Structure of human PNP complexed with ligands., Canduri F, Silva RG, dos Santos DM, Palma MS, Basso LA, Santos DS, de Azevedo WF Jr, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):856-62. Epub 2005, Jun 24. PMID:15983407

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