2kif

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==Solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.==
==Solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.==
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<StructureSection load='2kif' size='340' side='right'caption='[[2kif]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kif' size='340' side='right'caption='[[2kif]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibpq Vibpq]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus_AQ3810 Vibrio parahaemolyticus AQ3810]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIF FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A79_1377, VP0951 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419109 VIBPQ])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kif OCA], [https://pdbe.org/2kif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kif RCSB], [https://www.ebi.ac.uk/pdbsum/2kif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kif ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kif OCA], [https://pdbe.org/2kif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kif RCSB], [https://www.ebi.ac.uk/pdbsum/2kif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kif ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A6B4U8_VIBPH A6B4U8_VIBPH]] Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2]<ref>PMID:20212037</ref>
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[https://www.uniprot.org/uniprot/ATL_VIBPQ ATL_VIBPQ] Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins (By similarity).[UniProtKB:P0AFP2]<ref>PMID:20212037</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vibpq]]
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[[Category: Vibrio parahaemolyticus AQ3810]]
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[[Category: Acton, T B]]
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[[Category: Acton TB]]
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[[Category: Aramini, J M]]
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[[Category: Aramini JM]]
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[[Category: Belote, R L]]
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[[Category: Belote RL]]
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[[Category: Ciccosanti, C T]]
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[[Category: Ciccosanti CT]]
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[[Category: Everett, J K]]
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[[Category: Everett JK]]
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[[Category: Jiang, M]]
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[[Category: Jiang M]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: Nair R]]
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[[Category: Nair, R]]
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[[Category: Rost B]]
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[[Category: Rost, B]]
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[[Category: Swapna GVT]]
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[[Category: Swapna, G V.T]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Dna base repair]]
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[[Category: Methods development]]
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[[Category: Methyltransferase]]
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[[Category: Nesg]]
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[[Category: O6 methylguanine methyltransferase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Solution nmr structure]]
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[[Category: Transferase]]
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Current revision

Solution NMR structure of an O6-methylguanine DNA methyltransferase family protein from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium target VpR247.

PDB ID 2kif

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