2ktu

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Current revision (09:41, 22 May 2024) (edit) (undo)
 
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==Human eRF1 C-domain, "closed" conformer==
==Human eRF1 C-domain, "closed" conformer==
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<StructureSection load='2ktu' size='340' side='right'caption='[[2ktu]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''>
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<StructureSection load='2ktu' size='340' side='right'caption='[[2ktu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ktu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ktu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTU FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hst|2hst]], [[1dt9|1dt9]], [[2ktv|2ktv]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ETF1, ERF1, RF1, SUP45L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktu OCA], [https://pdbe.org/2ktu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktu RCSB], [https://www.ebi.ac.uk/pdbsum/2ktu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktu OCA], [https://pdbe.org/2ktu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktu RCSB], [https://www.ebi.ac.uk/pdbsum/2ktu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref>
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[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Birdsall, B]]
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[[Category: Birdsall B]]
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[[Category: Mantsyzov, A B]]
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[[Category: Mantsyzov AB]]
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[[Category: Polshakov, V I]]
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[[Category: Polshakov VI]]
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[[Category: C domain]]
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[[Category: Cytoplasm]]
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[[Category: Erf1]]
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[[Category: Eukaryote]]
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[[Category: Protein biosynthesis]]
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[[Category: Termination]]
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[[Category: Translation]]
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Current revision

Human eRF1 C-domain, "closed" conformer

PDB ID 2ktu

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