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3o6o

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Current revision (09:46, 22 May 2024) (edit) (undo)
 
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==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021==
==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021==
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<StructureSection load='3o6o' size='340' side='right' caption='[[3o6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3o6o' size='340' side='right'caption='[[3o6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6o OCA], [http://pdbe.org/3o6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o6o RCSB], [http://www.ebi.ac.uk/pdbsum/3o6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6o OCA], [https://pdbe.org/3o6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6o RCSB], [https://www.ebi.ac.uk/pdbsum/3o6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6o ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q389P1_TRYB2 Q389P1_TRYB2]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6o_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6o_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3o6o" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3o6o" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Trypanosoma brucei]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Cossar, D]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Fairlamb, A H]]
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[[Category: Cossar D]]
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[[Category: Ferguson, M A.J]]
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[[Category: Edwards AM]]
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[[Category: Hills, T]]
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[[Category: Fairlamb AH]]
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[[Category: Hui, R]]
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[[Category: Ferguson MAJ]]
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[[Category: Hutchinson, A]]
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[[Category: Hills T]]
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[[Category: Kozieradzki, I]]
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[[Category: Hui R]]
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[[Category: Li, Y]]
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[[Category: Hutchinson A]]
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[[Category: MacKenzie, C]]
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[[Category: Kozieradzki I]]
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[[Category: Pizarro, J C]]
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[[Category: Li Y]]
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[[Category: Structural genomic]]
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[[Category: MacKenzie C]]
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[[Category: Sullivan, H]]
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[[Category: Pizarro JC]]
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[[Category: Thompson, S]]
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[[Category: Sullivan H]]
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[[Category: Weadge, J]]
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[[Category: Thompson S]]
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[[Category: Weigelt, J]]
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[[Category: Weadge J]]
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[[Category: Wernimont, A K]]
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[[Category: Weigelt J]]
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[[Category: Wyatt, P]]
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[[Category: Wernimont AK]]
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[[Category: African sleeping sickness]]
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[[Category: Wyatt P]]
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[[Category: Chaperone]]
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[[Category: Heat shock protein]]
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[[Category: Sgc]]
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[[Category: Trypanosoma]]
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Current revision

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021

PDB ID 3o6o

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