3rpb

From Proteopedia

(Difference between revisions)

Current revision

THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN

Structural highlights

3rpb is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RP3A_RAT Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

C2 domains are widespread protein modules that often occur as tandem repeats in many membrane-trafficking proteins such as synaptotagmin and rabphilin. The first and second C2 domains (C2A and C2B, respectively) have a high degree of homology but also specific differences. The structure of the C2A domain of synaptotagmin I has been extensively studied but little is known about the C2B domains. We have used NMR spectroscopy to determine the solution structure of the C2B domain of rabphilin. The overall structure of the C2B domain is very similar to that of other C2 domains, with a rigid beta-sandwich core and loops at the top (where Ca2+ binds) and the bottom. Surprisingly, a relatively long alpha-helix is inserted at the bottom of the domain and is conserved in all C2B domains. Our results, together with the Ca(2+)-independent interactions observed for C2B domains, indicate that these domains have a Janus-faced nature, with a Ca(2+)-binding top surface and a Ca(2+)-independent bottom surface.

Structure of the Janus-faced C2B domain of rabphilin.,Ubach J, Garcia J, Nittler MP, Sudhof TC, Rizo J Nat Cell Biol. 1999 Jun;1(2):106-12. PMID:10559882^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ubach J, Garcia J, Nittler MP, Sudhof TC, Rizo J. Structure of the Janus-faced C2B domain of rabphilin. Nat Cell Biol. 1999 Jun;1(2):106-12. PMID:10559882 doi:10.1038/10076

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rpb"

@@ Line 1: / Line 1: @@
 ==THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN==
-<StructureSection load='3rpb' size='340' side='right'caption='[[3rpb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='3rpb' size='340' side='right'caption='[[3rpb]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RPB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3rpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RPB FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rpb OCA], [https://pdbe.org/3rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rpb RCSB], [https://www.ebi.ac.uk/pdbsum/3rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rpb ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rpb OCA], [https://pdbe.org/3rpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rpb RCSB], [https://www.ebi.ac.uk/pdbsum/3rpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rpb ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT]] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
+[https://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 31: @@
 ==See Also==
 *[[Exophilin 3D structures|Exophilin 3D structures]]
+*[[Rabphilin|Rabphilin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Garcia, J]]
+[[Category: Rattus norvegicus]]
-[[Category: Nittler, M P]]
+[[Category: Garcia J]]
-[[Category: Rizo, J]]
+[[Category: Nittler MP]]
-[[Category: Sudhof, T C]]
+[[Category: Rizo J]]
-[[Category: Ubach, J]]
+[[Category: Sudhof TC]]
-[[Category: C2-domain]]
+[[Category: Ubach J]]
-[[Category: C2b-domain]]
-[[Category: Endocytosis-exocytosis complex]]
-[[Category: Rabphilin]]

3rpb

From Proteopedia

Current revision

THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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