2j0q
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(New page: 200px<br /> <applet load="2j0q" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j0q, resolution 3.20Å" /> '''THE CRYSTAL STRUCTU...)
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Revision as of 16:29, 29 October 2007
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THE CRYSTAL STRUCTURE OF THE EXON JUNCTION COMPLEX AT 3.2 A RESOLUTION
Overview
The exon junction complex (EJC) plays a major role in posttranscriptional, regulation of mRNA in metazoa. The EJC is deposited onto mRNA during, splicing and is transported to the cytoplasm where it influences, translation, surveillance, and localization of the spliced mRNA. The, complex is formed by the association of four proteins (eIF4AIII, Barentsz, [Btz], Mago, and Y14), mRNA, and ATP. The 2.2 A resolution structure of, the EJC reveals how it stably locks onto mRNA. The DEAD-box protein, eIF4AIII encloses an ATP molecule and provides the binding sites for six, ribonucleotides. Btz wraps around eIF4AIII and stacks against the 5', nucleotide. An intertwined network of interactions anchors Mago-Y14 and, Btz at the interface between the two domains of eIF4AIII, effectively, stabilizing ... [(full description)]
About this Structure
2J0Q is a [Protein complex] structure of sequences from [Homo sapiens] with MG and ANP as [ligands]. Full crystallographic information is available from [OCA].
Reference
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA., Bono F, Ebert J, Lorentzen E, Conti E, Cell. 2006 Aug 25;126(4):713-25. PMID:16923391
Page seeded by OCA on Mon Oct 29 18:33:53 2007
Categories: Homo sapiens | Protein complex | Bono, F. | Conti, E. | Ebert, J. | Lorentzen, E. | ANP | MG | Acetylation | Alternative splicing | Atp-binding | Coiled coil | Dead-box helicase | Dna-binding | Ejc | Helicase | Hydrolase | Mrna processing | Mrna splicing | Mrna transport | Nonsense-mediated mrna decay | Nuclear protein | Nucleotide-binding | Phosphorylation | Rna-binding | Rrna processing | Transport
