7s5l
From Proteopedia
(Difference between revisions)
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==Cembrene A synthase from Eleutherobia rubra== | ==Cembrene A synthase from Eleutherobia rubra== | ||
| - | <StructureSection load='7s5l' size='340' side='right'caption='[[7s5l]]' scene=''> | + | <StructureSection load='7s5l' size='340' side='right'caption='[[7s5l]], [[Resolution|resolution]] 1.58Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S5L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eleutherobia_rubra Eleutherobia rubra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S5L FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s5l OCA], [https://pdbe.org/7s5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s5l RCSB], [https://www.ebi.ac.uk/pdbsum/7s5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s5l ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s5l OCA], [https://pdbe.org/7s5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s5l RCSB], [https://www.ebi.ac.uk/pdbsum/7s5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s5l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Octocorals are major contributors of terpenoid chemical diversity in the ocean. Natural products from other sessile marine animals are primarily biosynthesized by symbiotic microbes rather than by the host. Here, we challenge this long-standing paradigm by describing a monophyletic lineage of animal-encoded terpene cyclases (TCs) ubiquitous in octocorals. We characterized 15 TC enzymes from nine genera, several of which produce precursors of iconic coral-specific terpenoids, such as pseudopterosin, lophotoxin and eleutherobin. X-ray crystallography revealed that coral TCs share conserved active site residues and structural features with bacterial TCs. The identification of coral TCs enabled the targeted identification of the enzyme that constructs the coral-exclusive capnellane scaffold. Several TC genes are colocalized with genes that encode enzymes known to modify terpenes. This work presents an example of biosynthetic capacity in the kingdom Animalia that rivals the chemical complexity generated by plants, unlocking the biotechnological potential of octocorals for biomedical applications. | ||
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| + | Ancient plant-like terpene biosynthesis in corals.,Burkhardt I, de Rond T, Chen PY, Moore BS Nat Chem Biol. 2022 Jun;18(6):664-669. doi: 10.1038/s41589-022-01026-2. Epub 2022 , May 23. PMID:35606558<ref>PMID:35606558</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7s5l" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Eleutherobia rubra]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen PY-T]] | [[Category: Chen PY-T]] | ||
[[Category: Moore BS]] | [[Category: Moore BS]] | ||
Current revision
Cembrene A synthase from Eleutherobia rubra
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