8gci

Structural highlights

Function

PER_CAEEL Transcriptional repressor which interacts with the promoter region of target genes (PubMed:25032706). Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs (PubMed:16300753, PubMed:25032706, PubMed:25319259, PubMed:15691769, PubMed:29880558). Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58 (PubMed:24699545, PubMed:25032706, PubMed:25319259, PubMed:15691769, PubMed:29880558). Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells (PubMed:10550049, PubMed:21471153). Has a role in the miRNA-mediated specification of asymmetric gene expression patterns in gustatory neurons (PubMed:25032706). May also regulate genes involved in other biological processes including transport, small molecule metabolism, and growth (PubMed:25032706). Inhibits dauer formation, by antagonizing daf-12 (PubMed:20843862).^{[1] [2] [3] [4] [5] [6] [7] [8] [9]} Specifically required for maintaining the timing of larval development and molting cycle rhythms.^[10]

References

1. ↑ Jeon M, Gardner HF, Miller EA, Deshler J, Rougvie AE. Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins. Science. 1999 Nov 5;286(5442):1141-6. PMID:10550049 doi:10.1126/science.286.5442.1141
2. ↑ Banerjee D, Kwok A, Lin SY, Slack FJ. Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev Cell. 2005 Feb;8(2):287-95. PMID:15691769 doi:10.1016/j.devcel.2004.12.006
3. ↑ Tennessen JM, Gardner HF, Volk ML, Rougvie AE. Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42. Dev Biol. 2006 Jan 1;289(1):30-43. PMID:16300753 doi:10.1016/j.ydbio.2005.09.044
4. ↑ Tennessen JM, Opperman KJ, Rougvie AE. The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues. Development. 2010 Oct;137(20):3501-11. PMID:20843862 doi:10.1242/dev.048850
5. ↑ Huang X, Zhang H, Zhang H. The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. Development. 2011 May;138(10):2059-68. PMID:21471153 doi:10.1242/dev.057109
6. ↑ Van Wynsberghe PM, Finnegan EF, Stark T, Angelus EP, Homan KE, Yeo GW, Pasquinelli AE. The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. Dev Biol. 2014 Jun 15;390(2):126-35. PMID:24699545 doi:10.1016/j.ydbio.2014.03.017
7. ↑ Perales R, King DM, Aguirre-Chen C, Hammell CM. LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription. PLoS Genet. 2014 Jul 17;10(7):e1004486. PMID:25032706 doi:10.1371/journal.pgen.1004486
8. ↑ McCulloch KA, Rougvie AE. Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15450-5. PMID:25319259 doi:10.1073/pnas.1414856111
9. ↑ Rhodehouse K, Cascino K, Aseltine L, Padula A, Weinstein R, Spina JS, Olivero CE, Van Wynsberghe PM. The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans. G3 (Bethesda). 2018 Jul 31;8(8):2617-2629. PMID:29880558 doi:10.1534/g3.118.200392
10. ↑ Monsalve GC, Van Buskirk C, Frand AR. LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts. Curr Biol. 2011 Dec 20;21(24):2033-45. PMID:22137474 doi:10.1016/j.cub.2011.10.054