2b02
From Proteopedia
(Difference between revisions)
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<StructureSection load='2b02' size='340' side='right'caption='[[2b02]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2b02' size='340' side='right'caption='[[2b02]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2b02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2b02]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B02 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b02 OCA], [https://pdbe.org/2b02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b02 RCSB], [https://www.ebi.ac.uk/pdbsum/2b02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b02 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b02 OCA], [https://pdbe.org/2b02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b02 RCSB], [https://www.ebi.ac.uk/pdbsum/2b02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b02 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Botuyan | + | [[Category: Botuyan MV]] |
| - | [[Category: Lee | + | [[Category: Lee J]] |
| - | [[Category: Mer | + | [[Category: Mer G]] |
| - | [[Category: Nomine | + | [[Category: Nomine Y]] |
| - | [[Category: Ohh | + | [[Category: Ohh M]] |
| - | [[Category: Thompson | + | [[Category: Thompson JR]] |
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Current revision
Crystal Structure of ARNT PAS-B Domain
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Categories: Homo sapiens | Large Structures | Botuyan MV | Lee J | Mer G | Nomine Y | Ohh M | Thompson JR
