2cos
From Proteopedia
(Difference between revisions)
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==Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)== | ==Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)== | ||
| - | <StructureSection load='2cos' size='340' side='right'caption='[[2cos | + | <StructureSection load='2cos' size='340' side='right'caption='[[2cos]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2cos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cos OCA], [https://pdbe.org/2cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cos RCSB], [https://www.ebi.ac.uk/pdbsum/2cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cos ProSAT], [https://www.topsan.org/Proteins/RSGI/2cos TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cos OCA], [https://pdbe.org/2cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cos RCSB], [https://www.ebi.ac.uk/pdbsum/2cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cos ProSAT], [https://www.topsan.org/Proteins/RSGI/2cos TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LATS2_MOUSE LATS2_MOUSE] Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).<ref>PMID:15343267</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lk3 transgenic mice]] | ||
| - | [[Category: Transferase]] | ||
| - | [[Category: Hayashi, F]] | ||
| - | [[Category: Hirota, H]] | ||
| - | [[Category: Onuki, H]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Yokoyama, S]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: | + | [[Category: Hayashi F]] |
| - | [[Category: | + | [[Category: Hirota H]] |
| - | [[Category: | + | [[Category: Onuki H]] |
| - | [[Category: | + | [[Category: Yokoyama S]] |
Current revision
Solution structure of RSGI RUH-038, a UBA domain from Mouse LATS2 (Large Tumor Suppressor homolog 2)
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