2coz

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Current revision (11:28, 22 May 2024) (edit) (undo)
 
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==Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350==
==Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350==
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<StructureSection load='2coz' size='340' side='right'caption='[[2coz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2coz' size='340' side='right'caption='[[2coz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2coz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2coz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2COZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kazusa cDNA hh00807 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coz OCA], [https://pdbe.org/2coz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coz RCSB], [https://www.ebi.ac.uk/pdbsum/2coz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coz ProSAT], [https://www.topsan.org/Proteins/RSGI/2coz TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2coz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2coz OCA], [https://pdbe.org/2coz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2coz RCSB], [https://www.ebi.ac.uk/pdbsum/2coz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2coz ProSAT], [https://www.topsan.org/Proteins/RSGI/2coz TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CE350_HUMAN CE350_HUMAN]] Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.<ref>PMID:15615782</ref> <ref>PMID:16314388</ref> <ref>PMID:17878239</ref> <ref>PMID:18412956</ref> <ref>PMID:19052644</ref>
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[https://www.uniprot.org/uniprot/CE350_HUMAN CE350_HUMAN] Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.<ref>PMID:15615782</ref> <ref>PMID:16314388</ref> <ref>PMID:17878239</ref> <ref>PMID:18412956</ref> <ref>PMID:19052644</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Saito K]]
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[[Category: Saito, K]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Cytoskeleton associated protein]]
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[[Category: Microtubule binding]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein binding]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the CAP-Gly domain in human centrosome-associated protein CAP350

PDB ID 2coz

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