2ct4

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Current revision (11:30, 22 May 2024) (edit) (undo)
 
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==Solution Strutcure of the SH3 domain of the Cdc42-interacting protein 4==
==Solution Strutcure of the SH3 domain of the Cdc42-interacting protein 4==
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<StructureSection load='2ct4' size='340' side='right'caption='[[2ct4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ct4' size='340' side='right'caption='[[2ct4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ct4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ct4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CT4 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIP10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct4 OCA], [https://pdbe.org/2ct4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct4 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ct4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ct4 OCA], [https://pdbe.org/2ct4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ct4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ct4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ct4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ct4 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN]] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
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[https://www.uniprot.org/uniprot/CIP4_HUMAN CIP4_HUMAN] Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:11069762</ref> <ref>PMID:16326391</ref> <ref>PMID:16318909</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Miyamoto, K]]
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[[Category: Miyamoto K]]
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[[Category: Structural genomic]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Cdc42-interacting protein 4]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Thyroid receptor interacting protein 10]]
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Current revision

Solution Strutcure of the SH3 domain of the Cdc42-interacting protein 4

PDB ID 2ct4

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OCA

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