2d8c

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Current revision (11:35, 22 May 2024) (edit) (undo)
 
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==Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1==
==Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1==
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<StructureSection load='2d8c' size='340' side='right'caption='[[2d8c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2d8c' size='340' side='right'caption='[[2d8c]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8C FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">9530058O11Rik ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8c OCA], [https://pdbe.org/2d8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8c RCSB], [https://www.ebi.ac.uk/pdbsum/2d8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8c ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8c TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8c OCA], [https://pdbe.org/2d8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8c RCSB], [https://www.ebi.ac.uk/pdbsum/2d8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8c ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8c TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SMS1_MOUSE SMS1_MOUSE]] Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.<ref>PMID:16879426</ref> <ref>PMID:22580896</ref>
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[https://www.uniprot.org/uniprot/SMS1_MOUSE SMS1_MOUSE] Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.<ref>PMID:16879426</ref> <ref>PMID:22580896</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Goroncy, A K]]
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[[Category: Goroncy AK]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Tochio N]]
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[[Category: Tochio, N]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Cell-free protein synthesis]]
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[[Category: Lipid metabolism]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Protein regulation]]
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[[Category: Rsgi]]
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[[Category: Transferase]]
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Current revision

Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1

PDB ID 2d8c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

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