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2d9k
From Proteopedia
(Difference between revisions)
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==Solution structure of the zf-TRAF domain of FLN29 gene product== | ==Solution structure of the zf-TRAF domain of FLN29 gene product== | ||
| - | <StructureSection load='2d9k' size='340' side='right'caption='[[2d9k | + | <StructureSection load='2d9k' size='340' side='right'caption='[[2d9k]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2d9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2d9k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9K FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9k OCA], [https://pdbe.org/2d9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9k RCSB], [https://www.ebi.ac.uk/pdbsum/2d9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9k ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9k TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9k OCA], [https://pdbe.org/2d9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9k RCSB], [https://www.ebi.ac.uk/pdbsum/2d9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9k ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9k TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRAD1_HUMAN TRAD1_HUMAN] Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).<ref>PMID:16221674</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d9k ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d9k ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | + | [[Category: Suetake T]] | |
| - | [[Category: Suetake | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the zf-TRAF domain of FLN29 gene product
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