2dag
From Proteopedia
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==Solution Structure of the First UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)== | ==Solution Structure of the First UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)== | ||
| - | <StructureSection load='2dag' size='340' side='right'caption='[[2dag | + | <StructureSection load='2dag' size='340' side='right'caption='[[2dag]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2dag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2dag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAG FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dag OCA], [https://pdbe.org/2dag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dag RCSB], [https://www.ebi.ac.uk/pdbsum/2dag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dag ProSAT], [https://www.topsan.org/Proteins/RSGI/2dag TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dag OCA], [https://pdbe.org/2dag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dag RCSB], [https://www.ebi.ac.uk/pdbsum/2dag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dag ProSAT], [https://www.topsan.org/Proteins/RSGI/2dag TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Inoue M]] | |
| - | [[Category: Inoue | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Koshiba S]] |
| - | [[Category: Koshiba | + | [[Category: Tomizawa T]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Tomizawa | + | [[Category: Zhao C]] |
| - | [[Category: Yokoyama | + | |
| - | [[Category: Zhao | + | |
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Current revision
Solution Structure of the First UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Tomizawa T | Yokoyama S | Zhao C
