1v9u

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Revision as of 17:35, 12 November 2007

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spinqualitylabelsall models 1v9u, resolution 3.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Human Rhinovirus 2 bound to a fragment of its cellular receptor protein

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Although many viral receptors have been identified, the ways in which they, interact with their cognate viruses are not understood at the molecular, level. We have determined the X-ray structure of a complex between, calcium-containing modules of the very low-density lipoprotein receptor, and the minor group human rhinovirus HRV2. The receptor binds close to the, icosahedral five-fold vertex, with only one module per virus protomer. The, binding face of this module is defined by acidic calcium-chelating, residues and, in particular, by an exposed tryptophan that is highly, conserved. The attachment site on the virus involves only residues from, VP1, particularly a lysine strictly conserved in all minor group HRVs. The, disposition of the attached ligand-binding repeats around the five-fold, axis, together with the proximity of the N- and C-terminal ends of, adjacent modules, suggests that more than one repeat in a single receptor, molecule might attach simultaneously.

Disease

Known disease associated with this structure: Cerebellar hypoplasia, VLDLR-associated OMIM:[192977]

About this Structure

1V9U is a Protein complex structure of sequences from Homo sapiens and Human rhinovirus 2 with CA and DAO as ligands. Full crystallographic information is available from OCA.

Reference

X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:15064754

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