1sbu
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1sbu.gif|left|200px]] | [[Image:1sbu.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1sbu", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1sbu| PDB=1sbu | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2''' | '''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2''' | ||
| Line 27: | Line 24: | ||
[[Category: Figuet, M.]] | [[Category: Figuet, M.]] | ||
[[Category: Jourdan, M.]] | [[Category: Jourdan, M.]] | ||
| - | [[Category: | + | [[Category: Dimethyl-thiazolidine]] |
| - | [[Category: | + | [[Category: Molecular dynamics simulation]] |
| - | + | [[Category: Nmr spectroscopy]] | |
| - | [[Category: | + | [[Category: Vi beta turn]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:31:26 2008'' |
| - | + | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:31, 3 May 2008
NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2
Overview
The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
About this Structure
Full crystallographic information is available from OCA.
Reference
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:15326523 Page seeded by OCA on Sat May 3 08:31:26 2008
