1sds

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[[Image:1sds.gif|left|200px]]
[[Image:1sds.gif|left|200px]]
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{{Structure
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|PDB= 1sds |SIZE=350|CAPTION= <scene name='initialview01'>1sds</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1sds", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|GENE= RPL7AE, MJ1203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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{{STRUCTURE_1sds| PDB=1sds | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sds OCA], [http://www.ebi.ac.uk/pdbsum/1sds PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sds RCSB]</span>
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'''Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA'''
'''Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA'''
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[[Category: Amare, A Ferre-D.]]
[[Category: Amare, A Ferre-D.]]
[[Category: Hamma, T.]]
[[Category: Hamma, T.]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:35:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:40:41 2008''
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Revision as of 05:35, 3 May 2008

Image:1sds.gif

Template:STRUCTURE 1sds

Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA


Overview

The archaeal RNA binding protein L7Ae and its eukaryotic homolog 15.5 kDa/Snu13 recognize K-turns. This structural motif is canonically comprised of two stems (one with tandem A.G base pairs, the other with Watson-Crick pairs) linked by an asymmetric internal loop. L7Ae recognizes conventional K-turns in ribosomal and box C/D RNAs but also binds specifically to some box H/ACA RNAs at terminal stem loops. These have the A.G paired stem, but lack the Watson-Crick stem. The structure of Methanococcus jannaschii L7Ae bound to a symmetric duplex RNA without Watson-Crick stems demonstrates how a binding site for this component of diverse ribonucleoprotein complexes can be constructed with only the A.G stem and the loop. The RNA adopts a functional conformation with the aid of a base triple and tight binding of divalent cations. Comparison with the 15.5 kDa/Snu13-RNA complex structure suggests why the eukaryotic homolog does not recognize terminal stem loop L7Ae binding sites.

About this Structure

1SDS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution., Hamma T, Ferre-D'Amare AR, Structure. 2004 May;12(5):893-903. PMID:15130481 Page seeded by OCA on Sat May 3 08:35:09 2008

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