1sfk

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[[Image:1sfk.gif|left|200px]]
[[Image:1sfk.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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{{STRUCTURE_1sfk| PDB=1sfk | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sfk OCA], [http://www.ebi.ac.uk/pdbsum/1sfk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sfk RCSB]</span>
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'''Core (C) protein from West Nile Virus, subtype Kunjin'''
'''Core (C) protein from West Nile Virus, subtype Kunjin'''
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[[Category: Walsh, M.]]
[[Category: Walsh, M.]]
[[Category: Wang, S.]]
[[Category: Wang, S.]]
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[[Category: alpha helix]]
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[[Category: Alpha helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:38:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:41:21 2008''
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Revision as of 05:38, 3 May 2008

Image:1sfk.gif

Template:STRUCTURE 1sfk

Core (C) protein from West Nile Virus, subtype Kunjin


Overview

We have determined the crystal structure of the core (C) protein from the Kunjin subtype of West Nile virus (WNV), closely related to the NY99 strain of WNV, currently a major health threat in the U.S. WNV is a member of the Flaviviridae family of enveloped RNA viruses that contains many important human pathogens. The C protein is associated with the RNA genome and forms the internal core which is surrounded by the envelope in the virion. The C protein structure contains four alpha helices and forms dimers that are organized into tetramers. The tetramers form extended filamentous ribbons resembling the stacked alpha helices seen in HEAT protein structures.

About this Structure

1SFK is a Single protein structure of sequence from Kunjin virus. Full crystallographic information is available from OCA.

Reference

West Nile virus core protein; tetramer structure and ribbon formation., Dokland T, Walsh M, Mackenzie JM, Khromykh AA, Ee KH, Wang S, Structure. 2004 Jul;12(7):1157-63. PMID:15242592 Page seeded by OCA on Sat May 3 08:38:19 2008

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