1sg3

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[[Image:1sg3.gif|left|200px]]
[[Image:1sg3.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1sg3 |SIZE=350|CAPTION= <scene name='initialview01'>1sg3</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1sg3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Allantoicase Allantoicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.4 3.5.3.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DAL2, ALC1, YIR029W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1sg3| PDB=1sg3 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg3 OCA], [http://www.ebi.ac.uk/pdbsum/1sg3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sg3 RCSB]</span>
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'''Structure of allantoicase'''
'''Structure of allantoicase'''
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[[Category: Sorel, I.]]
[[Category: Sorel, I.]]
[[Category: Tilbeurgh, H van.]]
[[Category: Tilbeurgh, H van.]]
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[[Category: allantoicase]]
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[[Category: Allantoicase]]
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[[Category: hexamer]]
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[[Category: Hexamer]]
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[[Category: jelly roll]]
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[[Category: Jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:39:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:41:35 2008''
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Revision as of 05:39, 3 May 2008

Image:1sg3.gif

Template:STRUCTURE 1sg3

Structure of allantoicase


Overview

Allantoicase (EC 3.5.3.4) catalyzes the conversion of allantoate into ureidoglycolate and urea, one of the final steps in the degradation of purines to urea. The mechanism of most enzymes involved in this pathway, which has been known for a long time, is unknown. In this paper we describe the three-dimensional crystal structure of the yeast allantoicase determined at a resolution of 2.6 A by single anomalous diffraction. This constitutes the first structure for an enzyme of this pathway. The structure reveals a repeated jelly roll beta-sheet motif, also present in proteins of unrelated biochemical function. Allantoicase has a hexameric arrangement in the crystal (dimer of trimers). Analysis of the protein sequence against the structural data reveals the presence of two totally conserved surface patches, one on each jelly roll motif. The hexameric packing concentrates these patches into conserved pockets that probably constitute the active site.

About this Structure

1SG3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast allantoicase reveals a repeated jelly roll motif., Leulliot N, Quevillon-Cheruel S, Sorel I, Graille M, Meyer P, Liger D, Blondeau K, Janin J, van Tilbeurgh H, J Biol Chem. 2004 May 28;279(22):23447-52. Epub 2004 Mar 12. PMID:15020593 Page seeded by OCA on Sat May 3 08:39:35 2008

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