1sgv

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[[Image:1sgv.gif|left|200px]]
[[Image:1sgv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1sgv |SIZE=350|CAPTION= <scene name='initialview01'>1sgv</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1sgv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TRUB, RV2793C, MT2862.1, MTV002.58C, MB2816C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02573 PseudoU_synth_EcTruB], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK03287 truB]</span>
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{{STRUCTURE_1sgv| PDB=1sgv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sgv OCA], [http://www.ebi.ac.uk/pdbsum/1sgv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sgv RCSB]</span>
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}}
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'''STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)'''
'''STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)'''
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==About this Structure==
==About this Structure==
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1SGV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry 1S71. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SGV OCA].
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1SGV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1s71 1s71]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SGV OCA].
==Reference==
==Reference==
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Yeates, T O.]]
[[Category: Yeates, T O.]]
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[[Category: hinged motion]]
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[[Category: Hinged motion]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: Tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: Tbsgc]]
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[[Category: trna modification]]
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[[Category: Trna modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:41:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:41:49 2008''
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Revision as of 05:41, 3 May 2008

Image:1sgv.gif

Template:STRUCTURE 1sgv

STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)


Overview

The three-dimensional structure of the RNA-modifying enzyme, psi55 tRNA pseudouridine synthase from Mycobacterium tuberculosis, is reported. The 1.9-A resolution crystal structure reveals the enzyme, free of substrate, in two distinct conformations. The structure depicts an interesting mode of protein flexibility involving a hinged bending in the central beta-sheet of the catalytic module. Key parts of the active site cleft are also found to be disordered in the substrate-free form of the enzyme. The hinge bending appears to act as a clamp to position the substrate. Our structural data furthers the previously proposed mechanism of tRNA recognition. The present crystal structure emphasizes the significant role that protein dynamics must play in tRNA recognition, base flipping, and modification.

About this Structure

1SGV is a Single protein structure of sequence from Mycobacterium tuberculosis. This structure supersedes the now removed PDB entry 1s71. Full crystallographic information is available from OCA.

Reference

Crystal structure of the apo forms of psi 55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft., Chaudhuri BN, Chan S, Perry LJ, Yeates TO, J Biol Chem. 2004 Jun 4;279(23):24585-91. Epub 2004 Mar 17. PMID:15028724 Page seeded by OCA on Sat May 3 08:41:18 2008

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