1shz

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[[Image:1shz.gif|left|200px]]
[[Image:1shz.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1shz", creates the "Structure Box" on the page.
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{{STRUCTURE_1shz| PDB=1shz | SCENE= }}
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|RELATEDENTRY=[[1iap|1IAP]], [[1agr|1AGR]], [[1fqj|1FQJ]], [[1azs|1AZS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1shz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shz OCA], [http://www.ebi.ac.uk/pdbsum/1shz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1shz RCSB]</span>
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'''Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera'''
'''Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera'''
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[[Category: Sprang, S R.]]
[[Category: Sprang, S R.]]
[[Category: Sternweis, P C.]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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[[Category: signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:43:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:16 2008''
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Revision as of 05:43, 3 May 2008

Image:1shz.gif

Template:STRUCTURE 1shz

Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera


Overview

p115RhoGEF, a guanine nucleotide exchange factor (GEF) for Rho GTPase, is also a GTPase-activating protein (GAP) for G12 and G13 heterotrimeric Galpha subunits. The GAP function of p115RhoGEF resides within the N-terminal region of p115RhoGEF (the rgRGS domain), which includes a module that is structurally similar to RGS (regulators of G-protein signaling) domains. We present here the crystal structure of the rgRGS domain of p115RhoGEF in complex with a chimera of Galpha13 and Galphai1. Two distinct surfaces of rgRGS interact with Galpha. The N-terminal betaN-alphaN hairpin of rgRGS, rather than its RGS module, forms intimate contacts with the catalytic site of Galpha. The interface between the RGS module of rgRGS and Galpha is similar to that of a Galpha-effector complex, suggesting a role for the rgRGS domain in the stimulation of the GEF activity of p115RhoGEF by Galpha13.

About this Structure

1SHZ is a Protein complex structure of sequences from Homo sapiens and Mus musculus/rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator., Chen Z, Singer WD, Sternweis PC, Sprang SR, Nat Struct Mol Biol. 2005 Feb;12(2):191-7. Epub 2005 Jan 16. PMID:15665872 Page seeded by OCA on Sat May 3 08:43:38 2008

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