8snm

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Current revision (18:05, 29 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8snm is ON HOLD until Paper Publication
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==Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain==
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<StructureSection load='8snm' size='340' side='right'caption='[[8snm]], [[Resolution|resolution]] 3.84&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8snm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SNM FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.84&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8snm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8snm OCA], [https://pdbe.org/8snm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8snm RCSB], [https://www.ebi.ac.uk/pdbsum/8snm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8snm ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RHDF2_HUMAN RHDF2_HUMAN] Palmoplantar keratoderma-esophageal carcinoma syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RHDF2_HUMAN RHDF2_HUMAN] Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.[UniProtKB:Q80WQ6]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dai Y]]
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[[Category: Lee CH]]
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[[Category: Wang Y]]
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[[Category: Zhao H]]

Current revision

Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain

PDB ID 8snm

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OCA

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