9bol

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Current revision (18:10, 29 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9bol is ON HOLD until Paper Publication
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==Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5==
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<StructureSection load='9bol' size='340' side='right'caption='[[9bol]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9bol]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BOL FirstGlance]. <br>
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Description: Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ARP:(4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide'>A1ARP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Fairbrother, W.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bol OCA], [https://pdbe.org/9bol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bol RCSB], [https://www.ebi.ac.uk/pdbsum/9bol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bol ProSAT]</span></td></tr>
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[[Category: Murray, J.M]]
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</table>
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[[Category: Dipasquale, A]]
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== Function ==
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[[Category: Fuhrmann, J]]
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[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
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[[Category: Wu, H]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: DiPasquale A]]
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[[Category: Fairbrother WJ]]
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[[Category: Fuhrmann J]]
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[[Category: Murray JM]]
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[[Category: Wu H]]

Current revision

Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5

PDB ID 9bol

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