1si7

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[[Image:1si7.jpg|left|200px]]
[[Image:1si7.jpg|left|200px]]
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{{Structure
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|PDB= 1si7 |SIZE=350|CAPTION= <scene name='initialview01'>1si7</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1si7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TRUD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02575 PseudoU_synth_EcTruD], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02552 PseudoU_synth_TruD_like], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00984 truD]</span>
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{{STRUCTURE_1si7| PDB=1si7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1si7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1si7 OCA], [http://www.ebi.ac.uk/pdbsum/1si7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1si7 RCSB]</span>
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'''Structure of E. coli tRNA psi 13 pseudouridine synthase TruD'''
'''Structure of E. coli tRNA psi 13 pseudouridine synthase TruD'''
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[[Category: Malhotra, A.]]
[[Category: Malhotra, A.]]
[[Category: Ofengand, J.]]
[[Category: Ofengand, J.]]
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[[Category: novel fold]]
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[[Category: Novel fold]]
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[[Category: pseudouridine synthase]]
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[[Category: Pseudouridine synthase]]
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[[Category: trna]]
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[[Category: Trna]]
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[[Category: trud]]
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[[Category: Trud]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:44:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:25 2008''
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Revision as of 05:44, 3 May 2008

Image:1si7.jpg

Template:STRUCTURE 1si7

Structure of E. coli tRNA psi 13 pseudouridine synthase TruD


Overview

TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have been grouped into four related protein families. Crystal structure determination of TruD revealed a two domain structure consisting of a catalytic domain that differs in sequence but is structurally very similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 amino acids, 43% of total) with a novel alpha/beta fold that up to now has not been found in any other protein.

About this Structure

1SI7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold., Kaya Y, Del Campo M, Ofengand J, Malhotra A, J Biol Chem. 2004 Apr 30;279(18):18107-10. Epub 2004 Mar 3. PMID:14999002 Page seeded by OCA on Sat May 3 08:44:08 2008

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