2dky

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:43, 29 May 2024) (edit) (undo)
 
Line 1: Line 1:
==Solution structure of the SAM-domain of Rho-GTPase-activating protein 7==
==Solution structure of the SAM-domain of Rho-GTPase-activating protein 7==
-
<StructureSection load='2dky' size='340' side='right'caption='[[2dky]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2dky' size='340' side='right'caption='[[2dky]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2dky]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKY FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLC1, ARHGAP7, KIAA1723, STARD12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dky OCA], [https://pdbe.org/2dky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dky RCSB], [https://www.ebi.ac.uk/pdbsum/2dky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dky ProSAT], [https://www.topsan.org/Proteins/RSGI/2dky TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dky OCA], [https://pdbe.org/2dky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dky RCSB], [https://www.ebi.ac.uk/pdbsum/2dky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dky ProSAT], [https://www.topsan.org/Proteins/RSGI/2dky TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
+
[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 26: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Goroncy, A K]]
+
[[Category: Goroncy AK]]
-
[[Category: Inoue, M]]
+
[[Category: Inoue M]]
-
[[Category: Kigawa, T]]
+
[[Category: Kigawa T]]
-
[[Category: Koshiba, S]]
+
[[Category: Koshiba S]]
-
[[Category: Structural genomic]]
+
[[Category: Sato M]]
-
[[Category: Sato, M]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S]]
+
-
[[Category: Cell-free protein synthesis]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Protein regulation]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Signaling protein]]
+

Current revision

Solution structure of the SAM-domain of Rho-GTPase-activating protein 7

PDB ID 2dky

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dky"
Personal tools