2dlo

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==Solution structure of the second LIM domain of human Thyroid receptor-interacting protein 6==
==Solution structure of the second LIM domain of human Thyroid receptor-interacting protein 6==
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<StructureSection load='2dlo' size='340' side='right'caption='[[2dlo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2dlo' size='340' side='right'caption='[[2dlo]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2dlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2dlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x61|1x61]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIP6, OIP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlo OCA], [https://pdbe.org/2dlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlo RCSB], [https://www.ebi.ac.uk/pdbsum/2dlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlo ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlo TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlo OCA], [https://pdbe.org/2dlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlo RCSB], [https://www.ebi.ac.uk/pdbsum/2dlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlo ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlo TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN]] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref>
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[https://www.uniprot.org/uniprot/TRIP6_HUMAN TRIP6_HUMAN] Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.<ref>PMID:15489293</ref> <ref>PMID:14688263</ref> <ref>PMID:16624523</ref> <ref>PMID:19017743</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hayashi, F]]
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[[Category: Hayashi F]]
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[[Category: Qin, X R]]
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[[Category: Qin XR]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Cell adhesion]]
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[[Category: Lim domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Opa-interacting protein 1]]
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[[Category: Rsgi]]
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Current revision

Solution structure of the second LIM domain of human Thyroid receptor-interacting protein 6

PDB ID 2dlo

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