2e5o
From Proteopedia
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=='Solution structure of the TRIP_4C domain of target of activating signal cointegrator 1== | =='Solution structure of the TRIP_4C domain of target of activating signal cointegrator 1== | ||
| - | <StructureSection load='2e5o' size='340' side='right'caption='[[2e5o | + | <StructureSection load='2e5o' size='340' side='right'caption='[[2e5o]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5o OCA], [https://pdbe.org/2e5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5o RCSB], [https://www.ebi.ac.uk/pdbsum/2e5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5o TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5o OCA], [https://pdbe.org/2e5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5o RCSB], [https://www.ebi.ac.uk/pdbsum/2e5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5o ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5o TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TRIP4_HUMAN TRIP4_HUMAN] Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function (By similarity).<ref>PMID:12077347</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dang | + | [[Category: Dang W]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
'Solution structure of the TRIP_4C domain of target of activating signal cointegrator 1
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Categories: Homo sapiens | Large Structures | Dang W | Inoue M | Kigawa T | Muto Y | Shirouzu M | Terada T | Yokoyama S
