2e5r

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Current revision (18:47, 29 May 2024) (edit) (undo)
 
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==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)==
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<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2e5r' size='340' side='right'caption='[[2e5r]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E5R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DTNA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [https://pdbe.org/2e5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [https://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e5r ProSAT], [https://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[https://omim.org/entry/604169 604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
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[https://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dang, W]]
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[[Category: Dang W]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Structural genomic]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Dna binding protein]]
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[[Category: Dystrobrevin alpha]]
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[[Category: Dystrobrevin-alpha]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Zz domain]]
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Current revision

Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)

PDB ID 2e5r

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