2ecm
From Proteopedia
(Difference between revisions)
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==Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus== | ==Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus== | ||
| - | <StructureSection load='2ecm' size='340' side='right'caption='[[2ecm | + | <StructureSection load='2ecm' size='340' side='right'caption='[[2ecm]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ecm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECM FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [https://pdbe.org/2ecm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [https://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecm ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecm OCA], [https://pdbe.org/2ecm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecm RCSB], [https://www.ebi.ac.uk/pdbsum/2ecm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecm ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecm TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Harada | + | [[Category: Harada T]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Miyamoto | + | [[Category: Miyamoto K]] |
| - | + | [[Category: Watanabe S]] | |
| - | [[Category: Watanabe | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | [[Category: Yoneyama M]] |
| - | [[Category: Yoneyama | + | |
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Current revision
Solution structure of the RING domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus
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Categories: Large Structures | Mus musculus | Harada T | Kigawa T | Koshiba S | Miyamoto K | Watanabe S | Yokoyama S | Yoneyama M
