2ega

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Current revision (18:50, 29 May 2024) (edit) (undo)
 
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==Solution structure of the first SH3 domain from human KIAA0418 protein==
==Solution structure of the first SH3 domain from human KIAA0418 protein==
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<StructureSection load='2ega' size='340' side='right'caption='[[2ega]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ega' size='340' side='right'caption='[[2ega]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ega]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EGA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SH3MD1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ega OCA], [https://pdbe.org/2ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ega RCSB], [https://www.ebi.ac.uk/pdbsum/2ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ega ProSAT], [https://www.topsan.org/Proteins/RSGI/2ega TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ega FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ega OCA], [https://pdbe.org/2ega PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ega RCSB], [https://www.ebi.ac.uk/pdbsum/2ega PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ega ProSAT], [https://www.topsan.org/Proteins/RSGI/2ega TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN]] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>
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[https://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hayashi, F]]
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[[Category: Hayashi F]]
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[[Category: Inoue, K]]
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[[Category: Inoue K]]
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[[Category: Kurosaki, C]]
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[[Category: Kurosaki C]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M]]
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[[Category: Kiaa0418 protein]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Sh3 multiple domains 1]]
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[[Category: Sh3md1]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of the first SH3 domain from human KIAA0418 protein

PDB ID 2ega

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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