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2em0
From Proteopedia
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==Solution structure of the 18th zf-C2H2 domain from human Zinc finger protein 224== | ==Solution structure of the 18th zf-C2H2 domain from human Zinc finger protein 224== | ||
| - | <StructureSection load='2em0' size='340' side='right'caption='[[2em0 | + | <StructureSection load='2em0' size='340' side='right'caption='[[2em0]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2em0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2em0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EM0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em0 OCA], [https://pdbe.org/2em0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em0 RCSB], [https://www.ebi.ac.uk/pdbsum/2em0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em0 OCA], [https://pdbe.org/2em0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em0 RCSB], [https://www.ebi.ac.uk/pdbsum/2em0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em0 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Hayashi | + | [[Category: Hayashi F]] |
| - | [[Category: Kurosaki | + | [[Category: Kurosaki C]] |
| - | + | [[Category: Yokoyama S]] | |
| - | [[Category: Yokoyama | + | [[Category: Yoshida M]] |
| - | [[Category: Yoshida | + | |
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Current revision
Solution structure of the 18th zf-C2H2 domain from human Zinc finger protein 224
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