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2em7

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Current revision (18:52, 29 May 2024) (edit) (undo)
 
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==Solution structure of the C2H2 type zinc finger (region 339-371) of human Zinc finger protein 224==
==Solution structure of the C2H2 type zinc finger (region 339-371) of human Zinc finger protein 224==
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<StructureSection load='2em7' size='340' side='right'caption='[[2em7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2em7' size='340' side='right'caption='[[2em7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2em7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EM7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2em7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EM7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF224 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em7 OCA], [https://pdbe.org/2em7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em7 RCSB], [https://www.ebi.ac.uk/pdbsum/2em7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2em7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2em7 OCA], [https://pdbe.org/2em7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2em7 RCSB], [https://www.ebi.ac.uk/pdbsum/2em7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2em7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2em7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN]] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
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[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abe, H]]
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[[Category: Abe H]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Li, H]]
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[[Category: Li H]]
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[[Category: Structural genomic]]
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[[Category: Saito K]]
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[[Category: Saito, K]]
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[[Category: Sato M]]
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[[Category: Sato, M]]
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[[Category: Tochio N]]
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[[Category: Tochio, N]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Rsgi]]
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[[Category: Transcription]]
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[[Category: Zf-c2h2]]
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Current revision

Solution structure of the C2H2 type zinc finger (region 339-371) of human Zinc finger protein 224

PDB ID 2em7

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OCA

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