2ggp

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Current revision (18:59, 29 May 2024) (edit) (undo)
 
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==Solution structure of the Atx1-Cu(I)-Ccc2a complex==
==Solution structure of the Atx1-Cu(I)-Ccc2a complex==
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<StructureSection load='2ggp' size='340' side='right'caption='[[2ggp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ggp' size='340' side='right'caption='[[2ggp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ggp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ggp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GGP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATX1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), CCC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggp OCA], [https://pdbe.org/2ggp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggp RCSB], [https://www.ebi.ac.uk/pdbsum/2ggp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ggp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggp OCA], [https://pdbe.org/2ggp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ggp RCSB], [https://www.ebi.ac.uk/pdbsum/2ggp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ggp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ATX1_YEAST ATX1_YEAST]] Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity. [[https://www.uniprot.org/uniprot/ATU2_YEAST ATU2_YEAST]] Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.
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[https://www.uniprot.org/uniprot/ATX1_YEAST ATX1_YEAST] Shuttles copper to the transport ATPase CCC2. Protects against oxygen toxicity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
 
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[[Category: Copper-exporting ATPase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Banci, L]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Bertini, I]]
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[[Category: Banci L]]
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[[Category: Cantini, F]]
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[[Category: Bertini I]]
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[[Category: Felli, I C]]
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[[Category: Cantini F]]
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[[Category: Gonnelli, L]]
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[[Category: Felli IC]]
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[[Category: Hadjiliadis, N]]
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[[Category: Gonnelli L]]
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[[Category: Pierattelli, R]]
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[[Category: Hadjiliadis N]]
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[[Category: Rosato, A]]
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[[Category: Pierattelli R]]
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[[Category: SPINE, Structural Proteomics in Europe]]
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[[Category: Rosato A]]
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[[Category: Voulgaris, P]]
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[[Category: Voulgaris P]]
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[[Category: Chaperone]]
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[[Category: Complex]]
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[[Category: Copper transport]]
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[[Category: Metal transport]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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Current revision

Solution structure of the Atx1-Cu(I)-Ccc2a complex

PDB ID 2ggp

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