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2ghf
From Proteopedia
(Difference between revisions)
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==Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)== | ==Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)== | ||
| - | <StructureSection load='2ghf' size='340' side='right'caption='[[2ghf | + | <StructureSection load='2ghf' size='340' side='right'caption='[[2ghf]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ghf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ghf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GHF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghf OCA], [https://pdbe.org/2ghf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghf RCSB], [https://www.ebi.ac.uk/pdbsum/2ghf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ghf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ghf OCA], [https://pdbe.org/2ghf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ghf RCSB], [https://www.ebi.ac.uk/pdbsum/2ghf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ghf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZHX1_HUMAN ZHX1_HUMAN] Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.<ref>PMID:12237128</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Wienk H]] | |
| - | [[Category: Wienk | + | |
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Current revision
Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)
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