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2hd7

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Current revision (19:01, 29 May 2024) (edit) (undo)
 
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==Solution structure of C-teminal domain of twinfilin-1.==
==Solution structure of C-teminal domain of twinfilin-1.==
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<StructureSection load='2hd7' size='340' side='right'caption='[[2hd7]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2hd7' size='340' side='right'caption='[[2hd7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HD7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HD7 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ptk9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hd7 OCA], [https://pdbe.org/2hd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2hd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hd7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hd7 OCA], [https://pdbe.org/2hd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2hd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hd7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TWF1_MOUSE TWF1_MOUSE]] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.<ref>PMID:9249064</ref> <ref>PMID:10669753</ref> <ref>PMID:15282541</ref> <ref>PMID:16511569</ref>
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[https://www.uniprot.org/uniprot/TWF1_MOUSE TWF1_MOUSE] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.<ref>PMID:9249064</ref> <ref>PMID:10669753</ref> <ref>PMID:15282541</ref> <ref>PMID:16511569</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Annila, A]]
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[[Category: Annila A]]
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[[Category: Hellman, M H]]
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[[Category: Hellman MH]]
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[[Category: Lappalainen, P]]
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[[Category: Lappalainen P]]
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[[Category: Paavilainen, V O]]
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[[Category: Paavilainen VO]]
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[[Category: Permi, P I]]
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[[Category: Permi PI]]
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[[Category: Actin binding protein]]
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[[Category: Adf-h]]
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[[Category: Contractile protein]]
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Current revision

Solution structure of C-teminal domain of twinfilin-1.

PDB ID 2hd7

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