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2hw0

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Current revision (19:03, 29 May 2024) (edit) (undo)
 
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==NMR Solution Structure of the nuclease domain from the Replicator Initiator Protein from porcine circovirus PCV2==
==NMR Solution Structure of the nuclease domain from the Replicator Initiator Protein from porcine circovirus PCV2==
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<StructureSection load='2hw0' size='340' side='right'caption='[[2hw0]], [[NMR_Ensembles_of_Models | 31 NMR models]]' scene=''>
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<StructureSection load='2hw0' size='340' side='right'caption='[[2hw0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hw0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pcv2 Pcv2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hw0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_circovirus_2 Porcine circovirus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW0 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rep, ORF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85708 PCV2])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw0 OCA], [https://pdbe.org/2hw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw0 OCA], [https://pdbe.org/2hw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw0 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw0 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/REP_PCV2 REP_PCV2] Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep and/or Rep' binds a specific hairpin at the genome origin of replication. Introduces an endonucleolytic nick within the conserved sequence 5'-AGTATTAC-3' in the intergenic region of the genome, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, and nucleotidyl transferase.<ref>PMID:12954212</ref> <ref>PMID:25768890</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pcv2]]
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[[Category: Porcine circovirus 2]]
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[[Category: Byeon, I L]]
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[[Category: Byeon IL]]
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[[Category: Campos-Olivas, R]]
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[[Category: Campos-Olivas R]]
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[[Category: Gronenborn, A M]]
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[[Category: Gronenborn AM]]
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[[Category: Gronenborn, B]]
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[[Category: Gronenborn B]]
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[[Category: Vega-Rocha, S]]
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[[Category: Vega-Rocha S]]
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[[Category: Alpha+beta]]
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[[Category: Hydrolase]]
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[[Category: Replication]]
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Current revision

NMR Solution Structure of the nuclease domain from the Replicator Initiator Protein from porcine circovirus PCV2

PDB ID 2hw0

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OCA

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