2i8n
From Proteopedia
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==Solution structure of the second bromodomain of Brd4== | ==Solution structure of the second bromodomain of Brd4== | ||
| - | <StructureSection load='2i8n' size='340' side='right'caption='[[2i8n | + | <StructureSection load='2i8n' size='340' side='right'caption='[[2i8n]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2i8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2i8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I8N FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8n OCA], [https://pdbe.org/2i8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i8n RCSB], [https://www.ebi.ac.uk/pdbsum/2i8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i8n ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8n OCA], [https://pdbe.org/2i8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i8n RCSB], [https://www.ebi.ac.uk/pdbsum/2i8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i8n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu | + | [[Category: Liu Y]] |
| - | [[Category: Shi | + | [[Category: Shi YY]] |
| - | [[Category: Wu | + | [[Category: Wu JH]] |
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Current revision
Solution structure of the second bromodomain of Brd4
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Categories: Homo sapiens | Large Structures | Liu Y | Shi YY | Wu JH
