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2k2f

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Current revision (19:09, 29 May 2024) (edit) (undo)
 
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==Solution structure of Ca2+-S100A1-RyRP12==
==Solution structure of Ca2+-S100A1-RyRP12==
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<StructureSection load='2k2f' size='340' side='right'caption='[[2k2f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2k2f' size='340' side='right'caption='[[2k2f]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k2f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k2f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RYR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), S100a1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2f OCA], [https://pdbe.org/2k2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2f RCSB], [https://www.ebi.ac.uk/pdbsum/2k2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2f OCA], [https://pdbe.org/2k2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2f RCSB], [https://www.ebi.ac.uk/pdbsum/2k2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/S10A1_RAT S10A1_RAT]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
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[https://www.uniprot.org/uniprot/RYR2_RAT RYR2_RAT] Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.[UniProtKB:Q92736]<ref>PMID:20431056</ref> <ref>PMID:20471962</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Varney, K M]]
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[[Category: Varney KM]]
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[[Category: Weber, D J]]
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[[Category: Weber DJ]]
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[[Category: Wright, N T]]
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[[Category: Wright NT]]
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[[Category: Alternative splicing]]
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[[Category: Calcium binding]]
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[[Category: Calcium channel]]
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[[Category: Calcium transport]]
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[[Category: Cytoplasm]]
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[[Category: Ef hand]]
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[[Category: Glycoprotein]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Membrane]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Polymorphism]]
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[[Category: Ryanodine receptor]]
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[[Category: S100]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Zinc]]
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Current revision

Solution structure of Ca2+-S100A1-RyRP12

PDB ID 2k2f

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