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2klq
From Proteopedia
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==The solution structure of CBD of human MCM6== | ==The solution structure of CBD of human MCM6== | ||
| - | <StructureSection load='2klq' size='340' side='right'caption='[[2klq | + | <StructureSection load='2klq' size='340' side='right'caption='[[2klq]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2klq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2klq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klq OCA], [https://pdbe.org/2klq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klq RCSB], [https://www.ebi.ac.uk/pdbsum/2klq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klq ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klq OCA], [https://pdbe.org/2klq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klq RCSB], [https://www.ebi.ac.uk/pdbsum/2klq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/MCM6_HUMAN MCM6_HUMAN] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:9305914</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu | + | [[Category: Liu C]] |
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Current revision
The solution structure of CBD of human MCM6
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