1sj6

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[[Image:1sj6.gif|left|200px]]
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{{Structure
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|GENE= SHEBGRL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1sj6| PDB=1sj6 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj6 OCA], [http://www.ebi.ac.uk/pdbsum/1sj6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sj6 RCSB]</span>
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'''NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3'''
'''NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3'''
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[[Category: Zhang, Q.]]
[[Category: Zhang, Q.]]
[[Category: Zheng, P.]]
[[Category: Zheng, P.]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: thioredoxin]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:46:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:44 2008''
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Revision as of 05:46, 3 May 2008

Image:1sj6.gif

Template:STRUCTURE 1sj6

NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3


Overview

SH3 domain binding glutamic acid-rich protein like 3 (SH3BGRL3) is the new member of thioredoxin (TRX) super family, whose posttranslational modified form was identified as tumor necrosis factor alpha (TNF-alpha) inhibitory protein, TIP-B1. In this paper, we determined its solution structure by multi-dimensional nuclear magnetic resonance spectroscopy. The overall structure of human SH3BGRL3 conformed to a TRX-like fold. To understand its function in vivo, the upregulated expression in acute promyelocytic leukemia cell line NB4 at both mRNA and protein level was elucidated. Immunofluorescence and immunohistochemistry staining with monoclonal antibody against SH3BGRL3 demonstrated that it was a cytoplasmic protein in both NB4 cell and human tissues. These results, as a whole, indicate that SH3BGRL3 may function as a regulator in all-trans retinoic acid-induced pathway.

About this Structure

1SJ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NMR structure and regulated expression in APL cell of human SH3BGRL3., Xu C, Zheng P, Shen S, Xu Y, Wei L, Gao H, Wang S, Zhu C, Tang Y, Wu J, Zhang Q, Shi Y, FEBS Lett. 2005 May 23;579(13):2788-94. Epub 2005 Apr 20. PMID:15907482 Page seeded by OCA on Sat May 3 08:46:10 2008

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