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2yru
From Proteopedia
(Difference between revisions)
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==Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein== | ==Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein== | ||
| - | <StructureSection load='2yru' size='340' side='right'caption='[[2yru | + | <StructureSection load='2yru' size='340' side='right'caption='[[2yru]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yru]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YRU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yru OCA], [https://pdbe.org/2yru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yru RCSB], [https://www.ebi.ac.uk/pdbsum/2yru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yru ProSAT], [https://www.topsan.org/Proteins/RSGI/2yru TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yru OCA], [https://pdbe.org/2yru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yru RCSB], [https://www.ebi.ac.uk/pdbsum/2yru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yru ProSAT], [https://www.topsan.org/Proteins/RSGI/2yru TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SRA1_MOUSE SRA1_MOUSE] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).[UniProtKB:Q9HD15] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | [[Category: Nameki | + | [[Category: Nameki N]] |
| - | + | [[Category: Saito K]] | |
| - | [[Category: Saito | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of mouse Steroid receptor RNA activator 1 (SRA1) protein
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Categories: Large Structures | Mus musculus | Kigawa T | Koshiba S | Nameki N | Saito K | Yokoyama S
