4ry3
From Proteopedia
(Difference between revisions)
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==Crystal structure of human Fanconi-associated nuclease 1== | ==Crystal structure of human Fanconi-associated nuclease 1== | ||
| - | <StructureSection load='4ry3' size='340' side='right'caption='[[4ry3]]' scene=''> | + | <StructureSection load='4ry3' size='340' side='right'caption='[[4ry3]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RY3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4ry3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RY3 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ry3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ry3 OCA], [https://pdbe.org/4ry3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ry3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ry3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ry3 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.802Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ry3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ry3 OCA], [https://pdbe.org/4ry3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ry3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ry3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ry3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref> | ||
==See Also== | ==See Also== | ||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Huo YG]] | [[Category: Huo YG]] | ||
[[Category: Jiang T]] | [[Category: Jiang T]] | ||
[[Category: Yan PX]] | [[Category: Yan PX]] | ||
Current revision
Crystal structure of human Fanconi-associated nuclease 1
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