6kny

<table><tr><td colspan='2'>[[6kny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Akkm8 Akkm8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Amuc_1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349741 AKKM8])</td></tr>

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== Publication Abstract from PubMed ==

Many human diseases, such as obesity and diabetes, show annual increases in prevalence and often involve intestinal microbes. One such probiotic bacterium, Akkermansia muciniphila, which was discovered a decade ago, has been reported to influence glucose homeostasis and to contribute to gut health. Amuc_1100, a functionally uncharacterized protein of A. muciniphila, was found to be a key active component in reducing the body weight of mice. Here, the crystal structure of Amuc_1100 (residues 31-317), referred to as Amuc_1100*, is reported at 2.1 A resolution. Amuc_1100* has a similar fold to three proteins related to pilus formation, PilO, PilN and EpsL, indicating a similar function. Biochemical investigations further confirmed a monomeric state for the soluble region of Amuc_1100, which differs from the dimeric states of PilO, PilN and EpsL. This study provides a structural basis for the elucidation of the molecular mechanism of Amuc_1100.

Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.,Mou L, Peng X, Chen Y, Xiao Q, Liao H, Liu M, Guo L, Liu Y, Zhang X, Deng D Acta Crystallogr F Struct Biol Commun. 2020 Apr 1;76(Pt 4):168-174. doi:, 10.1107/S2053230X20004124. Epub 2020 Apr 1. PMID:32254050<ref>PMID:32254050</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 6kny" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Akkm8]]

[[Category: Deng, D]]

[[Category: Mou, L Q]]

[[Category: Xiao, Q J]]

[[Category: Unknown function]]