6u0r
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6u0r' size='340' side='right'caption='[[6u0r]], [[Resolution|resolution]] 2.91Å' scene=''> | <StructureSection load='6u0r' size='340' side='right'caption='[[6u0r]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U0R FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.91Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0r OCA], [https://pdbe.org/6u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u0r RCSB], [https://www.ebi.ac.uk/pdbsum/6u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0r OCA], [https://pdbe.org/6u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u0r RCSB], [https://www.ebi.ac.uk/pdbsum/6u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref> | ||
==See Also== | ==See Also== | ||
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Adeno-associated virus 2]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Agbandje-McKenna M]] | [[Category: Agbandje-McKenna M]] | ||
[[Category: Bennett A]] | [[Category: Bennett A]] | ||
Current revision
Cryo-EM structure of the chimeric vector AAV2.7m8
| |||||||||||
