1sjm

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[[Image:1sjm.gif|left|200px]]
[[Image:1sjm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1sjm |SIZE=350|CAPTION= <scene name='initialview01'>1sjm</scene>, resolution 1.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1sjm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NO2:NITRITE+ION'>NO2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrite_reductase_(NO-forming) Nitrite reductase (NO-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.2.1 1.7.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NIRK, NIR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=511 Alcaligenes faecalis])
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-->
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|DOMAIN=
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{{STRUCTURE_1sjm| PDB=1sjm | SCENE= }}
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|RELATEDENTRY=[[1j9q|1J9Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjm OCA], [http://www.ebi.ac.uk/pdbsum/1sjm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sjm RCSB]</span>
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}}
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'''Nitrite bound copper containing nitrite reductase'''
'''Nitrite bound copper containing nitrite reductase'''
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Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131305 15131305]
Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15131305 15131305]
[[Category: Alcaligenes faecalis]]
[[Category: Alcaligenes faecalis]]
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[[Category: Nitrite reductase (NO-forming)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Mauk, A G.]]
[[Category: Mauk, A G.]]
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[[Category: Rosell, F I.]]
[[Category: Rosell, F I.]]
[[Category: Tocheva, E I.]]
[[Category: Tocheva, E I.]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: nitrite]]
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[[Category: Nitrite]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:47:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:56 2008''
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Revision as of 05:47, 3 May 2008

Image:1sjm.gif

Template:STRUCTURE 1sjm

Nitrite bound copper containing nitrite reductase


Overview

A copper-nitrosyl intermediate forms during the catalytic cycle of nitrite reductase, the enzyme that mediates the committed step in bacterial denitrification. The crystal structure of a type 2 copper-nitrosyl complex of nitrite reductase reveals an unprecedented side-on binding mode in which the nitrogen and oxygen atoms are nearly equidistant from the copper cofactor. Comparison of this structure with a refined nitrite-bound crystal structure explains how coordination can change between copper-oxygen and copper-nitrogen during catalysis. The side-on copper-nitrosyl in nitrite reductase expands the possibilities for nitric oxide interactions in copper proteins such as superoxide dismutase and prions.

About this Structure

1SJM is a Single protein structure of sequence from Alcaligenes faecalis. Full crystallographic information is available from OCA.

Reference

Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:15131305 Page seeded by OCA on Sat May 3 08:47:10 2008

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